Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors

Chembiochem. 2003 Nov 7;4(11):1246-8. doi: 10.1002/cbic.200300724.

Authors

Ashraf Brik¹, John Muldoon, Ying-Chuan Lin, John H Elder, David S Goodsell, Arthur J Olson, Valery V Fokin, K Bary Sharpless, Chi-Huey Wong

Affiliation

¹ Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

PMID: 14613121
DOI: 10.1002/cbic.200300724

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Combinatorial Chemistry Techniques*
HIV Protease / chemistry*
HIV Protease / genetics
HIV Protease Inhibitors / chemical synthesis*
HIV Protease Inhibitors / chemistry
HIV-1 / enzymology*
Hydrogen Bonding
Molecular Structure
Mutation
Peptide Library*
Structure-Activity Relationship

Substances

HIV Protease Inhibitors
Peptide Library
HIV Protease